Creatinine is the by-product of creatine phosphate, which is produced at a constant rate and cleared from the blood by the kidneys. Normal creatinine levels in the blood are 0.6–1.3 mg/dL. Creatinine is a waste product that gets created in the body when muscle tissue and proteins are broken down. Your muscles have a high-energy molecule, called creatine phosphate.
Causes Of High Creatinine
High creatinine levels can be determined by doing blood tests. There are many health concerns that can weaken kidney functioning by increasing blood creatinine levels in the body. The most common causes of chronic kidney disease in adults are diabetes and high blood pressure. Other reasons for the high levels of creatinine may be, lupus, Goodpasture syndrome, gout, and muscular dystrophy.
- Kidney Disease
Chronic kidney disease, also called chronic kidney failure, involves a gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood. Advanced chronic kidney disease can cause dangerous levels of fluid, electrolytes, and wastes to build up in your body.
- Diet High in Protein
A high protein diet is a type of weight loss plan that emphasizes the consumption of high-protein-containing foods. A very high protein diet is one where 30% or more of the total daily calories come from protein. Higher protein diets may increase serum creatinine levels.
- Hypothyroidism
Thyroid eye disease (TED) is a condition that affects people who have hyperthyroidism. When a person has hyperthyroidism, the thyroid gland located in the throat produces excess levels of thyroid hormones. Creatinine values increase by about 34.4 percent after induction of hypothyroidism.
- Heart Failure
Kidney disease can affect your body’s ability to clean your blood, filter extra water out of your blood, and help control your blood pressure. A significant subset of patients with heart failure (HF) experience a small to moderate rise in serum creatinine
How kidney filter creatinine
Creatinine is a waste product that your body constantly makes during normal muscle breakdown. Your kidneys filter creatinine from the blood into the urine and reabsorb almost none of it. The amount of blood the kidneys can make creatinine-free each minute is called creatinine clearance. One of the main jobs of the kidneys is to filter the waste out of the blood.
How can high creatinine levels damage kidneys?
Creatinine is a waste product that is produced by your muscles. It is typically removed through the kidneys. Healthy kidneys filter creatinine out of your blood, elevated creatinine level signifies impaired kidney function or kidney disease. As the kidneys become impaired for any reason, the creatinine level in the blood will rise due to poor clearance of creatinine by the kidneys.
Can creatinine affect urine?
A urine creatinine test measures the amount of creatinine in the urine. It can be done on its own or with other tests that determine the amounts of other substances in the urine. Healthy kidneys filter the blood to rid it of waste products that the body can’t use. Low levels of creatinine in the urine may point to kidney disease, certain muscular and neuromuscular disorders, or a blockage in the urinary tract.
Creatinine clearance
A creatinine clearance test measures how well creatinine is removed from your blood by your kidneys. This test gives better information than a blood creatinine test on how well your kidneys are working. The test is done on both a blood sample and a sample of urine collected over 24 hours.